"In the past decade trying to imagine solutions that could help us meet major global issues," said Worldchanging co-founder and former executive editor Alex Steffen, in the ad. "This decade is about putting the solutions to work. This exciting new version of Worldchanging is, I think, to become the epicenter of online innovation applied. " Over the next six months AFH is the transformation of the open network architecture in a more robust platform which offers dialogue and support tools for architects and builders around the world, beyond its current database of building plans and architectural drawings. "We're delighted to connect with Worldchanging community to expand the ways we can continue to make a difference around the world. Each project requires innovative solutions, ingenuity and passion. This is a perfect fit, "said executive director of AFH, Cameron Sinclair. A year ago, Worldchanging board of directors announced that they would shut the doors of its 501 (c) 3 nonprofit that provides journalism based systems focused on a bright green future of this planet. Undoubtedly, the fusion of these two TED Prize winners is much better than letting one - we can only imagine the new power that come with their combined sustainable resources. + + Architecture for Humanity Worldchanging When cells divide normally, well DNA is copied and distributed to daughter cells with one hand yet. Occasionally though, DNA breaks during division and has been reorganized, leading to duplications or deletions of major portions of proyecto.Ahora, researchers at Baylor College of Medicine studying families with these disorders have found genomic shared responsibility However, unusual architecture resulting from this mixture that is associated with serious forms of the disease. We also identified genomic elements that produce such an architecture, a finding that will help predict other unstable regions in the genome humano.La unusual architecture left its mark, and the search for traces in other regions of the genome may identify regions that underwent the same alteration in the evolutionary past. This event could occur more frequently than expected. A report on their work appears online in the latest issue of Nature Genetics.Reordenamiento of the structure - the genetic material integrated into triple inverted duplication of genetic material - appeared in 20 percent of patients had been diagnosed with MECP2 duplication syndrome, said first author Dr. Claudia Carvalho, a postdoctoral associate in the laboratory of Dr. James Lupski, vice president of molecular and human genetics at BCM and informe.Una corresponding author of the MECP2 gene mutation was first identified in association with Rett syndrome by the laboratory of Dr. Huda Zoghbi at BCM. Rett's syndrome, the protein associated with the gene has little or no activity and the disorder primarily affects girls. Subsequent studies showed that the protein MeCP2 too much because of increased dose of the MECP2 gene can cause other serious illness - this time in boys and MECP2 duplicación.En syndrome called this new discovery, tripling patients with unusually complex - called in abbreviated form, DUP (duplication)-PRT (triplicate) / INV (inverted)-DUP - had a more severe constellation of symptoms associated with genomic disorders. Patients requiring oxygen or ventilator and hearing loss, heart defects and swallowing difficulties that necessitated a feeding tube. In most patients with the syndrome, developmental delays in motor skills, limited or absent speech, autistic behavior, mental retardation and recurrent infections are also typical symptoms. "Dr. Melissa Ramocki (another early authors of the paper and assistant professor of pediatrics - of neurology at BCM) began to be able to predict which patients are DUP-TRP/INV-DUP "said Lupski. This means that the greatest amount of genetic material increased the dose of MeCP2 protein and made empeore.Carvalho disorder suggests that the reorganization occurred during the generation of sperm cells. During meiosis (sex cell division), a cell divides and produces four haploid cells containing one copy of each chromosome. The resulting chromosomes in each gamete (sperm or egg) cells is a unique blend of paternal and maternal DNA, which ensures that children are genetically distinct from either parent. The process of copying DNA and the production of new lines for special cellular machinery existe.A Sometimes this process goes wrong. At one point, a piece of DNA replication machinery called the replication fork can collapse, forcing the cell to activate the repair process. When the cell tries to make a new fork, the DNA can be aligned properly and paired with a compatible piece of DNA apparently headed in the opposite direction. These elements called "inverted repeats" are very common in the human genome. This first event causes DNA replication in the wrong direction - as opposed to the way he was when the fork is collapsed, leading to an inverted segmental duplication. A second event, believed to be required for cell viability, will bring the new replication fork in the right direction and resume the replication process. This second event can now produce a three-fold if the new replication fork is restored within the region that was just copied two veces.Esta mix of machinery, matching the ends of DNA and abnormal reproduction of genetic material can cause the rearrangement tripling strange complexities of the disease, and appear to occur in more than duplication syndrome MECP2.El study of patients with other disorders associated with genomic PLP1 gene, the researchers were able to find the same unusual genomic architecture (The PLP1 gene is associated with Pelizaeus-Merzbacher disease, spastic paraplegia 2). In each case, inverted repeats of the genomic DNA sequence appear to help mediate the complex inverted triplication. "These investments are important," said Carvalho. "There is no easy way to test and do not know how common they are in the genome." "It is possible that a large number of disease genes and not see them there," said Lupski. "The same mechanism that causes the disease also may be involved in evolutionary change. In fact, this mechanism may have created new genes that could have been better suited to our environment. "Dr. Philip J. Hastings, professor of molecular and human genetics at BCM, who has studied the mutational events resulting in the rearrangement of the different genomes of many decades, helped discover how the rearrangements that can happen and is one of the authors of the report. Additional Dating References